Endocrine Abstracts

There is experimental evidence that inhibition of the glycogen synthase kinase-3β (GSK-3β) by small molecule inhibitors induces a rapid, CRM1/XPO1-dependent nuclear export of the AR protein in human prostate cancer cell lines. By contrast nucleo-cytoplasmic shuttling of Q641X, a C-terminally truncated AR-mutant, remains unaffected by GSK-3β inhibition. In silico analysis of the AR C-terminus (amino acids [aa] 641-920) predicted two putative NES-sites, l...